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Pre-Sterile Ampoule Filling Sealing Machine

Pre-Sterile Ampoule Filling Sealing Machine

To fill and seal type D pre-sterilized closed ampoules, one needs a pre-sterile ampoule filling machine. This Monoblock machine is well-known for its dependable operation and minimal maintenance requirements; it is equipped with an unscrambler, flushing, filling, and sealing functions. An apparatus with the "No Ampoule-No Filling System" specification. The ampoule filling equipment we offer can handle production-scale ampoules with ease.

The chemical, pharmaceutical, cosmetic, veterinary, and biotech industries all make extensive use of this machine. Our Ampoule Filling and Sealing Machines are designed to meet both our standard models and the special requirements of our customers.

  • Characteristics
  • Procedure
  • Technical Specification
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  • Slim GMP layout for optimal space utilization.
  • Apt for use in filling and sealing ampoules of type 'D'.
  • Constructed from Stainless Steel 304 for non-contact components and high-quality Stainless Steel 316L for all contact parts.
  • Minimal component size change accommodates ampoules from 1 ml to 10 ml.
  • "No Ampoule - No Filling" paradigm to ensure operational efficiency.
  • Maintains the ampoule's center during filling and gas flushing.
  • Nitrogen gas flushing is possible before, during, and after filling.
  • Easy maintenance enabled by full accessibility.
  • Features a pre-warming station for optimal product handling.
  • Very low wear and tear with easy upkeep and cleaning requirements.

The machine's slant hopper is designed to accept pre-sterilized D-type ampoule trays. The magazine-style cassette can hold one, two, four, six, or eight closed ampoules on an eccentric ampoule rack that moves. The ampoules are heated by the intense gas pressure as the lever that turns them turns. One way to open an ampoule is to pre-heat it and then use the gas pressure (LPG + oxygen) to open it. Ampoule opening, pre-gassing, filling, post-gassing, pre-heating, and final sealing are all accomplished during the rack standstill in sequential order. Without the need for manual handling, filled and sealed ampoules are automatically gathered in an upright stainless-steel tray.

Model LI-AFS 1C LI-AFS 2C LI-AFS 4C LI-AFS 6C
No. of Head Single Two Four Six
Direction of Movement Left to Right Left to Right Left to Right Left to Right
Ampoule Handling Range 1 ml to 10 ml 1 ml to 20 ml 1 ml to 5 ml 1 ml to 5 ml
Production Output 15 to 30 ampoules/minute 30 to 55 ampoules/minute 55 to 100 ampoules/minute 100 to 150 ampoules/minute
Filling Accuracy ± 1% ± 1% ± 1% ± 1%
Required Gas for Sealing LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂)
Nitrogen Pressure Required 1 Kg/cm² 1 Kg/cm² 1 Kg/cm² 1 Kg/cm²
Oxygen Pressure Required 1 Kg/cm² 1 Kg/cm² 1 Kg/cm² 1 Kg/cm²
LPG Pressure Required 0.5 Kg/cm² 0.5 Kg/cm² 0.5 Kg/cm² 0.5 Kg/cm²
Power Specification 0.5 H.P 1 H.P. 1 H.P. 1 H.P.
Electrical Characteristics 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L
Non-Contact Parts Made from Stainless Steel 304 Made from Stainless Steel 304 Made from Stainless Steel 304 Made from Stainless Steel 304
Overall Dimension 915mm (L) x 610mm (W) x 965mm (H) 915mm (L) x 760mm (W) x 965mm (H) 1200mm (L) x 1070mm (W) x 965mm (H) 1200mm (L) x 1070mm (W) x 965mm (H)

* Specification can be changed as per customers’ requirements

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Frequently Asked Questions

Common questions about Pre-Sterile Ampoule Filling Sealing Machine

Pre-Sterile Ampoule Filling Sealing Machine is a sterile/aseptic-compatible machine used in injectable pharmaceutical manufacturing. Manufactured by Lodha International LLP in Ahmedabad, Gujarat, India, it is built with SS 316L stainless-steel contact parts to cGMP, WHO-GMP and CE-compliant specifications and is used worldwide in injectable pharmaceutical, parenteral, biologics and sterile drug manufacturing applications.

Pre-Sterile Ampoule Filling Sealing Machine is used across injectable pharmaceutical, parenteral, biologics and sterile drug manufacturing. It is also routinely supplied to contract manufacturers, government labs and turnkey facility projects. View our global client list spanning 100+ countries.

The Pre-Sterile Ampoule Filling Sealing Machine is priced on a per-project basis, typically ranging from ₹50,000 for entry-level semi-automatic models to ₹50 lakh+ for fully automatic, high-speed configurations. Final price depends on capacity (output per hour), automation level, container size, head count, materials of construction and destination country. Request a free quote for accurate pricing.

Capacity ranges typically from 1,200 to 12,000 units/hour depending on configuration, container size, viscosity and number of heads. Lodha designs sterile injectable filling lines for vials, ampoules and infusion bottles from bench-scale R&D throughput to fully automatic commercial output. Specific BPM (bottles per minute) figures are confirmed at quotation stage.

Yes — Lodha International LLP builds the Pre-Sterile Ampoule Filling Sealing Machine to cGMP, WHO-GMP and CE-marked standards, with optional 21 CFR Part 11 software compliance for the HMI/PLC. All product-contact surfaces use SS 316L stainless steel, and complete IQ / OQ / PQ validation documentation is supplied on request. The company itself is ISO 9001:2015 certified.

Standard manufacturing lead time is 8 to 14 weeks from confirmed order, plus 2 to 6 weeks for international shipping depending on destination. Urgent orders can sometimes be expedited to 5–7 weeks at additional cost. Country-specific certification (EU CE, US FDA, ANVISA) may add 2 to 4 weeks.

Yes — the Pre-Sterile Ampoule Filling Sealing Machine is exported to 100+ countries across Asia, the Middle East, Africa, Europe, the Americas and Oceania. Lodha handles complete export documentation, packing, freight forwarding, customs liaison and on-site installation in the destination country. See the turnkey projects page for delivered references.

On-site installation, commissioning, IQ / OQ / PQ qualification, operator training and preventive maintenance are included for every Pre-Sterile Ampoule Filling Sealing Machine delivery. Remote troubleshooting is available 24/7 by phone, email and video. Spare parts are stocked at the Ahmedabad HQ and air-shipped within 5–7 working days to any export destination. A 12-month manufacturing warranty applies.