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Sterile Powder Filling Machine

Sterile Powder Filling Machine

Lodha Machine is the leading manufacturer of the sterile vial powder filling machine. The automatic sterile vial powder filling and rubber stoppering machine is a fully mechanical- operate system with a self-picking roller-based stoppering mechanism. The filling process utilizes a vacuum and air pressure-based powder wheel, allowing for manual adjustment of fill weight. This machine is designed for round glass vials and can achieve a maximum speed of 120 vials per minute. The model LI-PVF is constructed with a stainless-steel finish, including the machine's frame structure, adhering to cGMP standards. This sterile vial powder filling machine has high accuracy and quality in dry powder filling, making it incredibly easy to operate. It effectively minimizes powder wastage while maintaining a high throughput, capable of producing 120 fills per minute for a single dose, 60 fills per minute for a double dose, 40 fills per minute for a triple dose, and 30 fills per minute for a quadruple dose.

The sterile powder filling machine offers several advanced features to Improve performance and accuracy. All contact parts are made of SS316 material, allowing easy removal for autoclaving and sterilization. The machine's construction in SS304 material that has durability and compliance with industry standards.

Key features include a no vial - no fill system, separate variable speed operate for the powder hopper, and a unique design that prevents cross-contamination during powder charging.The hopper can be entirely dismantled for complete cleaning, minimal residue and reducing powder wastage.The tool-less adjustment of the doctor blade and wiper blade saves valuable time, and the built-in rubber stoppering system make sure perfect and proper sealing. The machine also includes multiple dosing systems, built-in turntables with separate operates for infeed and outfeed speed control, and various safety features, including a clutch system for vial breakage. With automatic infeed and exit of vials and a well-designed powder hopper, this machine meets all current application needs and trouble-free long-term operation.

  • Features
  • Process Operation
  • Technical Specification
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  • The machine won't fill the vial if it's not in place
  • All parts that touch the powder are made of a special material that can be easily removed for sterilization
  • The machine is made of a strong and durable material
  • The speed of the powder hopper can be adjusted separately
  • The design of the powder hopper prevents any mixing of powders during filling
  • The hopper can be taken apart for easy cleaning
  • Very little powder is left in the hopper after each batch, reducing waste
  • It's easy to adjust the doctor blade and wiper blade without needing tools, saving time
  • Changing the powder hopper and well agitator is tool-less and simple
  • The machine is very perfect, with an error margin of just 1% when the humidity is controlled below 30%
  • It has a built-in system for adding rubber stoppers to the vials
  • It can handle multiple doses using different parts
  • Built-in turntables control the speed of vial input and output
  • Safety features include a clutch system to prevent vial breakage
  • The machine has good clearance underneath and maintains proper spacing for vial handling
  • The moving conveyor above the top plate is designed to meet current needs
  • The machine automatically feeds vials in and removes them after filling
  • The design of the powder hopper make sure no mixing of powders
  • The machine stops if there's no stopper, low air pressure, or low vacuum
  • The mounting system for the powder wheel is heavy-duty for trouble-free long-term operation

The operation of the sterile vial powder filling machine begins with sterilized powder stored in the powder hopper, which is agitated by mechanical agitators to maintain consistent bulk density. The powder wheel, equipped with eight ports and pistons, rotates at a predetermined speed beneath the powder hopper with minimal clearance. Vacuum pressure make sure perfect powder volume is sucked into the ports, and excess powder is removed by an adjustable doctor blade. The powder is then transferred into containers using compressed air or nitrogen gas, confirming accurate and clean filling. The filled containers go to the stoppering station after being separated on the conveyor.

At the stoppering station, sterilized and siliconized rubber stoppers stored in a vibratory bowl are vertically stacked and fed into the stopper chute. The containers are held securely between timing belts, and the rubber stoppers are placed onto the vials. This entire process confirms that the powder is filled accurately and efficiently into the containers, with minimal waste and high quality, making the sterile powder filling machine an essential tool for pharmaceutical production.

Model Number LI-PVF 4
Vial Diameter 25mm to 38mm
Vial Height 75mm Maximum
Rubber Stopper Diameter 20mm
Filling Range 50mg to 1.5 gm In Single Dose, 1.5 gm to 6 gm In Double, Triple and Four Dose system
Accuracy +/- 1% Depending upon the Powder, under the controlled level of Humidity
Humidity Below 30% Rh required on machine to be arrange by customer
Electrical 415VAC 3Phase and 220 VAC Single Phase Power Supply (50 Hz) with A.C. Drive
Power 2.0 H.P.
Compressed Air Filtered, Oil Free 4kg/cm2 provided by customer only
Vacuum 28โ€ Hg. @ 300 LPM, provided by Customers only, 500LPM recommended
Conveyor Height 815-940 mm
Overall Dimensions 2800 mm (L) x 840 mm (W) x 1675 mm, Model AHPF-120
Production Output Max. 120 Vials per minute in Single Dose, Max. 60 Vials per minute in Double Dose, Max. 40 Vials per minute in Triple Dose and Max. 30 Vials per minute in Four Dose system

* Power voltage can be adjusted as per customerโ€™s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

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Frequently Asked Questions

Common questions about Sterile Vial Powder Filling Machine

Sterile Vial Powder Filling Machine is a sterile/aseptic-compatible machine used in injectable pharmaceutical manufacturing. Manufactured by Lodha International LLP in Ahmedabad, Gujarat, India, it is built with SS 316L stainless-steel contact parts to cGMP, WHO-GMP and CE-compliant specifications and is used worldwide in injectable pharmaceutical, parenteral, biologics and sterile drug manufacturing applications.

Sterile Vial Powder Filling Machine is used across injectable pharmaceutical, parenteral, biologics and sterile drug manufacturing. It is also routinely supplied to contract manufacturers, government labs and turnkey facility projects. View our global client list spanning 100+ countries.

The Sterile Vial Powder Filling Machine is priced on a per-project basis, typically ranging from โ‚น50,000 for entry-level semi-automatic models to โ‚น50 lakh+ for fully automatic, high-speed configurations. Final price depends on capacity (output per hour), automation level, container size, head count, materials of construction and destination country. Request a free quote for accurate pricing.

Capacity ranges typically from 1,200 to 12,000 units/hour depending on configuration, container size, viscosity and number of heads. Lodha designs sterile injectable filling lines for vials, ampoules and infusion bottles from bench-scale R&D throughput to fully automatic commercial output. Specific BPM (bottles per minute) figures are confirmed at quotation stage.

Yes โ€” Lodha International LLP builds the Sterile Vial Powder Filling Machine to cGMP, WHO-GMP and CE-marked standards, with optional 21 CFR Part 11 software compliance for the HMI/PLC. All product-contact surfaces use SS 316L stainless steel, and complete IQ / OQ / PQ validation documentation is supplied on request. The company itself is ISO 9001:2015 certified.

Standard manufacturing lead time is 8 to 14 weeks from confirmed order, plus 2 to 6 weeks for international shipping depending on destination. Urgent orders can sometimes be expedited to 5โ€“7 weeks at additional cost. Country-specific certification (EU CE, US FDA, ANVISA) may add 2 to 4 weeks.

Yes โ€” the Sterile Vial Powder Filling Machine is exported to 100+ countries across Asia, the Middle East, Africa, Europe, the Americas and Oceania. Lodha handles complete export documentation, packing, freight forwarding, customs liaison and on-site installation in the destination country. See the turnkey projects page for delivered references.

On-site installation, commissioning, IQ / OQ / PQ qualification, operator training and preventive maintenance are included for every Sterile Vial Powder Filling Machine delivery. Remote troubleshooting is available 24/7 by phone, email and video. Spare parts are stocked at the Ahmedabad HQ and air-shipped within 5โ€“7 working days to any export destination. A 12-month manufacturing warranty applies.